目的　观察间断补充铁剂预防孕妇铁缺乏的疗效。方法　随机抽取孕妇 62名 ,采用蛋白琥珀酸铁 (菲普利 ) ,于孕 2 2～ 2 6周开始每四周补充 1 2 0 mg元素铁。于孕 2 2～ 2 6周、32～ 34周、37～ 39周检测血红蛋白 (Hb)、锌原卟啉 (ZPP)、血清铁蛋白 (SF)及红细胞内铁蛋白 (EF) ,与未预防组和正常对照组比较。结果　未预防性补铁的孕妇铁营养状况随月份增加而逐渐下降 ;预防组补铁后 Hb、SF、EF均显著升高 ,ZPP显著降低 ,且优于同期未预防组 ;这两组各期 SF、EF均明显低于正常对照组 (P <0 .0 5)。结论　孕妇从孕中期开始每四周一次补充蛋白琥珀酸铁(1 2 0 mg元素铁 ) ,可有效阻止铁储存量下降 ,对孕期铁缺乏的发生具有一定的预防作用 Objective To observe the efficacy of intermittent iron supplementation in preventing iron deficiency in pregnant women. Methods Totally 62 pregnant women were enrolled in the study. Ferric protein succinate (FEP) was supplemented with 120 mg of elemental iron every four weeks starting from 2 to 26 weeks of gestation. Hemoglobin (Hb), zinc protoporphyrin (ZPP), serum ferritin (SF) and erythrocyte ferritin (EF) were detected at 22 to 26, 32 to 34 and 37 to 39 weeks of gestation, Group and normal control group. Results The iron nutrition status of pregnant women with non-preventive iron supplementation decreased gradually with the increase of the month. The levels of Hb, SF and EF in the prevention group were significantly increased and ZPP was significantly lower than those in the non-prevention group SF, EF were significantly lower than the normal control group (P <0.05). Conclusion Pregnant women supplemented with iron ferric succinate (120 mg of elemental iron) once every four weeks from the second trimester of pregnancy can effectively prevent the decrease of iron storage and have a preventive effect on the occurrence of iron deficiency during pregnancy