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探讨性激素雌二醇 (E2 )、睾酮 (T)在激素诱导的兔股骨头坏死中的作用 ,并评价补肾植物药 (右归饮 )、动物药 (鹿马片 )对激素诱导的兔股骨头坏死的防治效果。用外源性糖皮质激素诱导的家兔股骨头坏死的动物模型 ,动态观察血浆中 E2 、T含量的变化 ,同时观察助肾阳的动、植物药对其的防治效果。结果显示激素诱导的兔股骨头坏死模型组 E2 、T含量明显降低 ,右归饮能拮抗E2 的降低 ,不能拮抗 T的降低。鹿马片能拮抗 E2 、T的降低 ,使之恢复平衡 ,而且其升高幅度比右归饮明显 ,两者比较有差异。病理观察结果表明 ,鹿马片的防治效果优于右归饮。说明 E2 、T分泌不足在骨坏死中可能起重要作用。温补肾阳的中药能够预防激素性股骨头坏死 ,且动物药疗效好于植物药。
To investigate the role of sex hormones estradiol (E2) and testosterone (T) in hormone-induced necrosis of femoral head in rabbits and to evaluate the effect of kidney-reinforcing herbal medicine (Youguiyin) and animal medicine (Luma tablet) on hormone-induced femoral head in rabbits Necrosis control effect. Animal models of femoral head necrosis induced by exogenous glucocorticoids were used to dynamically observe changes in plasma E2 and T levels, and at the same time, the preventive and therapeutic effects of active and botanical drugs to help kidney yang were observed. The results showed that hormone-induced femoral head necrosis of the rabbit model group E2, T content was significantly reduced, right Guiyin can antagonize the reduction of E2, can not antagonize the reduction of T. Deer horse tablets can antagonize the reduction of E2 and T and restore the balance, and the increase rate is more obvious than that of Yougui drinking. There are differences between the two. The results of pathological observation showed that the prevention and treatment effect of Luma Tablets was better than that of Yougui Drink. It shows that the lack of secretion of E2 and T may play an important role in osteonecrosis. Warming kidney-yang Chinese medicine can prevent hormone-induced femoral head necrosis, and animal medicines are better than botanicals.