结直肠癌是消化系统常见的恶性肿瘤,患者常存在凝血指标异常。血浆纤维蛋白原直接参与凝血过程,其水平增高可致体内凝血和纤溶系统失衡,而且其在结直肠癌的发生发展和复发转移中扮演了重要角色。本文简要总结了纤维蛋白原的结构和作用,及其在结直肠癌中的实际临床意义。 Colorectal cancer is a common malignant tumor of the digestive system, patients often have coagulation abnormalities. Plasma fibrinogen directly involved in coagulation process, the level can cause in vivo coagulation and fibrinolytic system imbalance, and its role in the occurrence and development of colorectal cancer and recurrence and metastasis. This article briefly summarizes the structure and role of fibrinogen and its clinical significance in colorectal cancer.