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目的 :已知褪黑素 (M)对生殖系统有抑制作用 ,提示生殖系统是M作用的靶器官 ,生殖系统上可能存在褪黑素受体 (MR)。方法 :MR检测方法在放射配体结合法。 [1 2 5I]褪黑素 ( 1 2 5I·M ,81 40× 1 0 1 0 Bq/mmol)为中科院上海原子能所产品。结果 :1 [1 2 5I·M
OBJECTIVES: It is known that melatonin (M) has an inhibitory effect on the reproductive system, suggesting that the reproductive system is the target organ for M action and that melatonin receptors (MR) may be present on the reproductive system. Methods: MR detection was performed by radioligand binding assay. [1 2 5I] Melatonin (1 2 5I · M, 81 40 × 10 01 Bq / mmol) is a product of Shanghai Institute of Atomic Energy. Results: 1 [1 2 5I · M