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目的探讨血清IL-18、IL-6及CRP水平在多囊卵巢综合征患者(PCOS)患者中的变化及其临床意义。方法分别应用酶联免疫吸附法和免疫透射比浊法检测64例PCOS患者血清IL-18、IL-6及CRP含量,并与64例正常对照组比较分析。结果 PCOS患者血清IL-18、IL-6、CRP及HOMA-IR水平较健康对照组升高(P<0.05);且PCOS肥胖型患者血清IL-18、IL-6、CRP及HOMA-IR水平较非肥胖型明显升高(P<0.05);血清IL-18、IL-6、CRP水平与HOMA-IR均呈明显正相关(r=0.639,r=0.657,r=0.708,均P<0.01)。结论 PCOS可能是一种慢性亚临床炎症反应状态,炎症因子的明显增加,导致炎症损伤,并和胰岛素抵抗关系密切,而肥胖可能作为一种慢性亚临床炎症反应加重PCOS的异常。
Objective To investigate the changes of serum IL-18, IL-6 and CRP levels in patients with polycystic ovary syndrome (PCOS) and its clinical significance. Methods Serum levels of IL-18, IL-6 and CRP in 64 patients with PCOS were detected by enzyme-linked immunosorbent assay (ELISA) and immunoturbidimetry respectively, and compared with 64 normal controls. Results Serum levels of IL-18, IL-6, CRP and HOMA-IR in PCOS patients were significantly higher than those in healthy controls (P <0.05). Serum levels of IL-18, IL-6, CRP and HOMA-IR in obese PCOS patients The levels of IL-18, IL-6 and CRP were positively correlated with HOMA-IR (r = 0.639, r = 0.657, r = 0.708, all P <0.01) ). Conclusions PCOS may be a chronic sub-clinical inflammatory reaction state with a marked increase of inflammatory factors leading to inflammatory injury and is closely related to insulin resistance. However, obesity may be an abnormality of PCOS as a chronic subclinical inflammatory reaction.