动脉粥样硬化与脂质(尤其是载脂蛋白)代谢异常有关。目前已知载脂蛋白(Apo)有8种,本文拟浅述ApoA、ApoB与动脉粥样硬化的关系。一、ApoA 已有研究表明,血浆ApoA-Ⅰ含量与动脉粥样硬化呈负相关。ApoA-Ⅰ是体内抗动脉粥样硬化的因素之一,其和高密度脂蛋白(HDL)可将周围组织细胞的游离胆固醇酯化,并转运到肝脏进一步代谢,以防外周组织的脂质沉积和粥样硬化。ApoA-Ⅰ和磷脂结合可加强上述作用,有助于细胞内胆固醇 Atherosclerosis and lipid (especially apolipoprotein) metabolic abnormalities. At present, there are 8 kinds of apolipoproteins (Apo), this article to be brief on ApoA, ApoB and atherosclerosis relationship. First, ApoA studies have shown that plasma ApoA-Ⅰ content and atherosclerosis was negatively correlated. ApoA-I is one of the anti-atherogenic factors in vivo, and HDL can esterify free cholesterol from surrounding tissue cells and transport it to the liver for further metabolism to prevent lipid deposition in peripheral tissues And atherosclerosis. ApoA-Ⅰ and phospholipids can enhance the above-mentioned role, contribute to intracellular cholesterol