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目的 :检测慢性乙型肝炎患者血清可溶性Fas (sFas)水平 ,并探讨其在肝炎发病机理中的作用和临床意义。方法 :用ELISA法检测了 42例慢性乙型肝炎和 2 0例正常人血清sFas浓度。结果 :慢性乙型肝炎患者血清sFas浓度为 (6 1± 3 4)ng/ml,明显高于正常对照组 (t =2 463 ,P <0 0 1 )。PCR -HRV -DNA阳性组与PCR -HBV -DNA阴性组血清sFas无显著性差异。sFas与多项肝炎活动程度指标呈正相关。结论 :血中sFas在慢性乙型肝炎发病过程中可能起着重要作用 ,检测病人血中sFas水平可作为慢性乙型肝炎疾病活动性指标。
Objective: To detect the level of soluble Fas (sFas) in patients with chronic hepatitis B and to explore its role in the pathogenesis of hepatitis and its clinical significance. Methods: Serum sFas concentrations in 42 patients with chronic hepatitis B and 20 normal controls were detected by ELISA. Results: Serum sFas levels in patients with chronic hepatitis B were significantly higher than those in controls (t 1 = 463, P <0.01). Serum sFas in PCR-HRV-DNA positive group and PCR-HBV-DNA negative group had no significant difference. sFas and a number of indicators of hepatitis activity was positively correlated. Conclusion: sFas in blood may play an important role in the pathogenesis of chronic hepatitis B. The level of sFas in blood can be used as an index of disease activity of chronic hepatitis B.