脓毒症是临床危重病患者主要死亡原因之一。肠道既是脓毒症极易受累的器官，又是脓毒症病程进展的始动器官，因此，改善肠道屏障功能是治疗脓毒症的关键。近年来研究表明，自噬参与脓毒症病理过程，通过清除受损细胞器维持线粒体功能，进而抑制炎症、氧化应激及凋亡，调节免疫、维持肠道稳态，改善脓毒症病情及预后，是脓毒症有效治疗靶点。硫化氢（Hn 2S）作为新型医学气体信号分子，可通过调节多个信号通路调控自噬，已成为脓毒症治疗研究的新靶向。本文对脓毒症肠损伤时Hn 2S调控自噬的信号通路调节机制进行综述。n “,”Sepsis is one of the main causes of death in critically ill patients. The intestinal tract is not only the organ easily involved in sepsis, but also the initial organ in the progression of sepsis, so the improvement of intestinal barrier function is the key of the treatment of sepsis. In recent years, it has been found that autophagy is involved in the pathological process of sepsis, maintaining mitochondrial function by clearing damaged organelles, inhibiting inflammation, oxidative stress and apoptosis, regulating immunity, maintaining intestinal homeostasis, and improving the condition and prognosis of sepsis. It is an effective target for the treatment of sepsis. As a new type of medical gas signal molecule, hydrogen sulfide (Hn 2S) can regulate autophagy by regulating multiple signal pathways, which has become a new target in the treatment of sepsis. This article reviews the signal pathway regulation mechanism of Hn 2S regulating autophagy in septic intestinal dysfunction.n