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目的观察当归总苯酞在活血化瘀方面的功效。方法大鼠ig给予当归总苯酞(生药1、2、4 g/kg),观察当归总苯酞对大鼠实验性动脉血栓形成及血小板聚集功能的影响;采用高分子右旋糖酐制备高黏血症大鼠模型,观察当归总苯酞对大鼠血液黏度的影响;观察当归总苯酞对大鼠凝血相关指标的影响。结果当归总苯酞(生药1、2、4 g/kg)能延长大鼠实验性动脉血栓的形成时间(P<0.05、0.01);降低高分子右旋糖苷所致的高黏血症大鼠全血、血浆、血清黏度(P<0.05);抑制花生四烯酸(AA)、腺苷二磷酸钠(ADP)、胶原(CG)诱导的血小板聚集功能(P<0.05、0.01、0.001);明显延长大鼠凝血酶时间(TT)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)(P<0.05、0.01、0.001)。结论当归总苯酞具有显著的活血化瘀作用,表现为延长实验性动脉血栓的形成时间;改善高黏血症模型大鼠的全血及血浆黏度;抑制血小板聚集功能;影响凝血系统,延长大鼠TT、PT、APTT等指标。
Objective To observe the efficacy of Angelica total phthalide in promoting blood circulation. Methods The rats were given ig with total phthalide (1,2,4 g / kg crude drug) to observe the effect of Angelica total phthalide on experimental arterial thrombosis and platelet aggregation in rats. High molecular dextran was used to prepare hyperviscosity Rat model to observe the effect of Angelica Total Benzenephthalein on blood viscosity of rats; observe the effect of Angelica Total Benzenephthalein on coagulation related indicators in rats. Results Angelica total phthalide (crude drug 1, 2, 4 g / kg) can prolong the formation of experimental arterial thrombosis in rats (P <0.05, 0.01); reduce high molecular dextran-induced hyperviscosity rat (P <0.05); inhibit platelet aggregation induced by arachidonic acid (AA), adenosine diphosphate (ADP) and collagen (CG) (P <0.05,0.01,0.001); Significantly prolonged thrombin time (TT), prothrombin time (PT), activated partial thromboplastin time (APTT) (P <0.05,0.01,0.001). Conclusion Angelica total phthalide has a significant role in promoting blood circulation and removing blood stasis, which is to prolong the formation time of experimental arterial thrombosis, improve whole blood and plasma viscosity, inhibit platelet aggregation in hyperviscosity model rats, influence coagulation system, Rat TT, PT, APTT and other indicators.