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应用图像分析技术，对18例小肝癌和38例大肝癌行DNA含量测定，并分析其肿瘤生物学特性，结果显示小肝癌DNA含量以低倍异倍体为主（66．7％），大肝癌以高倍异倍体为主（94．7％），P<0．01，在肿瘤包膜突破和癌栓形成率上小肝癌（11．1％和22．2％）明显低于大肝癌（P<0．01），小肝癌存在明显的不典型增生，预后优于大肝癌，而病理分级，肝硬变程度两组无显著差异。提示＜3cm的小肝癌基本反映了早期肝癌的肿瘤生物学特征，是获得根治性切除的良好时机。DNA含量测定是估计肝癌恶性程度和临床预后的准确和客观的指标。
Image analysis technology was used to determine the DNA content of 18 cases of small hepatocellular carcinoma and 38 cases of large hepatocarcinoma, and the biological characteristics of the tumor were analyzed. The results showed that the DNA content of small hepatocellular carcinoma was mainly low aneuploidy (66.7%). The hepatocellular carcinoma was mainly composed of high aneuploidy (94.7%), P<0.01. The small hepatocellular carcinoma (11.1% and 22.2%) was significantly lower than the large hepatocellular carcinoma in the tumor capsule breakthrough rate and tumor embolus formation rate. (P<0.01). The small hepatocellular carcinoma had obvious dysplasia and the prognosis was better than that of the large hepatocellular carcinoma. There was no significant difference between the two groups in pathological grade and cirrhosis degree. Tip <3cm of small hepatocellular carcinoma basically reflects the biological characteristics of early stage of liver cancer, is a good opportunity to obtain radical resection. The determination of DNA content is an accurate and objective indicator of the degree of malignancy and clinical prognosis of liver cancer.