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1915年山际和同事市川在东京帝国大学用溶解于苯的煤焦油反复擦抹于白兔的耳朵上,发现有鳞状上皮细胞癌产生。这一成功的发现成为国际公认的环境化学物质致癌研究的一个里程碑。1923年日本在化学物质致癌研究上又出现了第二次突破。在佐佐木指导下,吉田通过给大鼠喂饲含有邻氨基偶氮甲苯的饲料,结果诱发了大鼠的肝脏肉瘤。接着,大阪帝国大学的木下又发现4-二甲基氨基偶氮苯
In 1915, Hiroyuki Ichikawa and his colleague Ichikawa repeatedly wiped the ears of white rabbits with coal tar dissolved in benzene at Tokyo Imperial University to find squamous cell carcinoma. This successful discovery has become an internationally recognized landmark for the carcinogenicity of environmental chemicals. In 1923, Japan made a second breakthrough in the study of chemical carcinogenesis. Under the guidance of Sasaki, Yoshida induced rat liver sarcoma by feeding rats a diet containing o-azo-azotoluene. Next, 4-dimethylaminoazobenzene was found under the Kinoshita in Osaka Imperial University