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目的:建立十一味甘露丸中木香烃内酯和去氢木香内酯的含量测定方法。方法:HPLC法测定十一味甘露丸中木香烃内酯和去氢木香内酯的含量。采用C18,甲醇-水(6238)为流动相,检测波长225nm。结果:木香烃内酯在(0.247~1.235)mg/mL的浓度范围内呈现良好的线性关系(r=0.997 8),平均回收率为100.81%(RSD=3.28%);去氢木香内酯在(0.404 2~2.021)mg/mL范围内有良好的线性关系(r=0.997 6),平均回收率为99.73%(RSD=2.91%)。结论:本方法简便易行、专属性强、分离度好、测定结果准确可靠、灵敏、重现性好,能有效地控制该制剂的质量。
OBJECTIVE: To establish a method for the determination of the content of wood-like lactone and dehydrocostuslane in eleven-sweetglular pill. Methods: HPLC method was used to determine the content of linalool and dehydrocostuslane in 11 Yawei Ganlu pills. Using C18, methanol - water (62 38) as the mobile phase, detection wavelength of 225nm. Results: The linear range was 0.247 ~ 1.235 mg / mL (r = 0.997 8) and the average recovery was 100.81% (RSD = 3.28%). (0.404 2 ~ 2.021) mg / mL (r = 0.997 6). The average recovery was 99.73% (RSD = 2.91%). Conclusion: The method is simple and easy to use, with high specificity, good resolution, accurate and reliable determination results, good sensitivity and reproducibility, and can effectively control the quality of the preparation.