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体内药物及其代谢产物的分析研究为药物浓度、药效和毒性之间的关系、药物作用机理及药代动力学的研究提供了科学依据。因此,近年来的进展令人瞩目,已成为药物分析的一项新课题。1 HPLC 法在体内药物分析中的应用1.1 生物样品的前处理欲测生物样品中的药物,首先应除去内源性成分的干扰,保证色谱柱的柱效和寿命。
In vivo drug and its metabolites of the study for the concentration of drugs, the relationship between efficacy and toxicity, drug mechanism of action and pharmacokinetic studies provide a scientific basis. Therefore, the remarkable progress made in recent years has become a new topic for drug analysis. 1 HPLC method in the application of in vivo drug analysis 1.1 biological sample pretreatment To test biological samples of drugs, first of all should remove the interference of endogenous components, to ensure the column efficiency and life expectancy.