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用IFN治疗病毒性感染包括病毒性肝炎有两个基本方法:(1)注射IFN制剂;(2)刺激机体内IFN合成。作者研究单独使用苏联产Reaferon(α_2-IFN)、或并用IFN诱导剂治疗急性乙型肝炎的效果。用细菌性脂多糖灵杆菌素和非类固醇抗炎药布洛芬作为诱导剂,不仅能刺激内源性IFN合成,而且有良好的免疫调节作用,改善机体的非特异性反应指标。观察急性乙型肝炎56例,年龄17～67岁,血清HBsAg阳性。未用IFN治疗24例为对照组;用IFN治疗32例,分3组,第1组13例,注射Reaferon 1×10~6IU,每日2次(间隔12h)共5天;第2组9例,并用灵杆菌素注射3～4次,从20μg增至100μg;第3组10例,并用布洛芬内服,200mg每日3次共14天。治疗前、后检查外周血T、B淋
There are two basic approaches to the treatment of viral infections, including viral hepatitis, with IFN: (1) injection of IFN preparations; (2) stimulation of IFN synthesis in the body. The authors studied the effects of using either Soviet-derived Reaferon (α_2-IFN) alone or in combination with IFN-inducing agents in the treatment of acute hepatitis B. Bacterial lipopolysaccharide and bacitracin and non-steroidal anti-inflammatory drugs ibuprofen as an inducer, not only can stimulate endogenous IFN synthesis, but also a good immune regulation, to improve the body’s non-specific response indicators. 56 cases of acute hepatitis B were observed, aged 17 to 67 years old, serum HBsAg positive. Twenty-four non-IFN treated patients served as the control group; 32 patients were treated with IFN, divided into three groups, group 1 received 13 doses of Reaferon 1 × 10 ~ 6 IU twice daily (interval 12 h) Cases, and the injection of sreptomycin 3 to 4 times, from 20μg to 100μg; Group 3 in 10 cases, and with oral administration of ibuprofen, 200mg 3 times a day for a total of 14 days. Before and after treatment, check the blood T, B lymph