肾小球硬化是多种原因引起肾小球损伤后出现的共同转归 ,是肾功能衰竭的主要病理基础。而导致肾小球硬化最主要的原因就是系膜细胞增生和细胞外基质增多 ,其中细胞外基质的增多与系膜细胞增生又密切相关[1] 。因此 ,探讨肾小球系膜细胞增生的内部机制以及如何对其进行调控 ,已 Glomerulosclerosis is a common prognosis of glomerular damage caused by a variety of reasons, is the main pathological basis of renal failure. The leading cause of glomerulosclerosis is the mesangial cell proliferation and extracellular matrix increased, of which extracellular matrix and mesangial cell proliferation is closely related to [1]. Therefore, to explore the internal mechanism of glomerular mesangial cell proliferation and how to regulate it