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目的探讨TP方案和NP方案治疗晚期非小细胞肺癌的疗效和毒副反应。方法采用随机法分为TP(紫杉醇+顺铂)组和NP(长春瑞滨+顺铂)组。结果 TP和NP两组有效率分别是63%和55.6%。两组比较疗效均无显著性差异。两组毒副反应,表现为骨髓抑制,恶心呕吐,周围神经毒性反应,过敏反应,脱发,静脉炎,肝功能损害等均可耐受,两组无显著性差异。结论 TP方案和NP方案治疗晚期非小细胞肺癌具有较好的临床疗效,毒副反应相似且均可耐受。
Objective To investigate the curative effect and toxicity of TP regimen and NP regimen in the treatment of advanced non-small cell lung cancer. Methods Randomly divided into TP (paclitaxel + cisplatin) group and NP (vinorelbine + cisplatin) group. Results The effective rates of TP and NP were 63% and 55.6% respectively. There was no significant difference between the two groups. Two groups of side effects, manifested as myelosuppression, nausea and vomiting, peripheral neurotoxic reactions, allergic reactions, hair loss, phlebitis, liver damage, etc. were tolerable, no significant difference between the two groups. Conclusion TP and NP regimens have good clinical efficacy in the treatment of advanced non-small cell lung cancer with similar side effects and tolerability.