论文部分内容阅读
[目的]探讨高压氧（HBO）联合常规疗法综合治疗病毒性脑炎的疗效及对肿瘤坏死因子α（TNF-α）、神经元特异性烯醇化酶（NSE）、S100b蛋白、白介素-6（IL-6）、C-反应蛋白（CRP）水平的影响。[方法]选择病毒性脑炎患儿125例，按照入院的先后顺序分为两组，对照组63例，采用常规治疗，观察组62例，采用高压氧＋常规治疗法，比较两组疗效及TNF-α、NSE、S100b蛋白、IL-6、CRP水平。[结果]观察组的总有效率为96．8％，显著高于对照组的74．6％（ P ＜0．05）；两组患儿的TNF-α、IL-6、NSE、S100b蛋白和CRP水平均随治疗逐渐下降，观察组下降显著低于对照组（P ＜0．05），IL-6值显著高于对照组（P ＜0．05）。[结论]高压氧联合常规疗法综合治疗病毒性脑炎疗效安全、有效，值得临床推广应用。“,”[Objective]To explore the efficacy of hyperbaric oxygen (HBO) combined with conventional therapy in comprehensive treatment of viral encephalitis and the influence on the levels of tumor necrosis factor alpha (TNF-α) ,neu-ronspecific enolase(NSE) ,S100b protein ,interleukin-6(IL-6) and C-reactive protein(CRP) .[Methods]Totally 125 pe-diatric patients with viral encephalitis were chosen .According to the order of admission ,all patients were divided into two groups .The control group( n =63) was given conventional therapy ,while the observation group ( n = 62) was given HBO combined with conventional treatment .The efficacy and the influence on TNF-α,NSE ,S100b protein ,IL-6 and CRP were compared between two groups .[Results]The total effective rate of observation group was 96 .8% ,which was significantly higher than that of control group (74 .6% )( P <0 .05) .The levels of TNF-α,IL-6 ,NSE ,S100b protein and CRP in two groups decreased gradually under the treatment ,and the decreasing in observation group was significantly lower than that in control group ( P<0 .05) ,IL-6 in observation group was significantly higher than that in control group ( P<0 .05) .[Conclusion] HBO combined with conventional treatment is safe and effective in the treatment of viral en-cephalitis ,so it is worthy of clinical popularization and application .