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为评价流行性出血热（ＥＨＦ）疫苗接种对机体细胞免疫功能的影响，作者初步探讨了疫苗免疫小鼠脾细胞增殖及产生白细胞介素－２（ＩＬ－２）的能力，结果表明：疫苗免疫小鼠脾细胞对刀豆素Ａ（ＣｏｎＡ）的增殖指数为１０１．１７±３３．７２，正常对照小鼠为７９．８５±２０．６０，·免疫组显著高于正常对照组（Ｐ＜０．０５），疫苗免疫组对流行性出血热病毒（ＥＨＦｖ）抗原的增殖指数为３．８３±２．０９，显著高于正常对照组（０．７５±０．３４，Ｐ＜０．０１）．两组小鼠脾细胞在ＣｏｎＡ诱导下产生ＩＬ－２的活性则免疫组显著高于对照组（Ｐ＜０．０１），上述结果表明，灭活疫苗接种可提高小鼠淋巴细胞增殖能力，且对病毒抗原的刺激产生明显的ＩＬ－２反应．
To evaluate the effect of epidemic hemorrhagic fever (EHF) vaccination on cellular immune function, the authors initially explored the ability of spleen cells to proliferate and produce interleukin-2 (IL-2) in vaccinated mice. The results showed that the vaccine immunized The proliferation index of mouse spleen cells against ConA was 101.17 ± 33.72, while that of normal control mice was 79.85 ± 20.60. The immune group was significantly higher than that of the normal control group (P <0. .05). The proliferation index of epidemic hemorrhagic fever virus (EHFv) antigen in vaccine group was 3.83 ± 2.09, which was significantly higher than that in control group (0.75 ± 0.34, P <0.01) . The activity of IL-2 induced by ConA in the two groups of mice was significantly higher than that of the control group (P <0.01). These results indicated that inactivated vaccination could increase the lymphocyte proliferation ability of mice Stimulation of viral antigens produced a significant IL-2 response.