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目的:考察克痔栓对实验性痔疮的影响及其安全性。方法:采用角叉菜胶致大鼠肛周肿胀、醋酸致大鼠肛周溃疡建立实验性痔疮模型,观察克痔栓对实验性痔疮模型的治疗作用。并观察克痔栓的止血作用和毒性。结果:克痔栓对角叉菜胶致大鼠肛周肿胀及醋酸所致大鼠肛周溃疡有显著治疗作用,对小鼠断尾止血作用显著(P<0.05),未出现明显毒性反应。结论:克痔栓对动物实验性痔疮治疗效果确切。
Objective: To investigate the effect and safety of Keluan suppository on experimental acne. METHODS: Rats with perianal swelling caused by carrageenan and acetic acid-induced perianal ulcers were used to establish experimental acne models. The therapeutic effect of Kefu Suppository on experimental acne models was observed. Observe the hemostatic effect and toxicity of Keqi suppository. RESULTS: Keluan suppository had a significant therapeutic effect on the perianal swelling of rats induced by carrageenan and acetic acid-induced perianal ulceration in rats, and had a significant hemostatic effect on mice after tail injury (P<0.05). No significant toxic reaction was observed. Conclusion: Keluan suppository has an exact effect on experimental acne in animals.