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为了进一步探讨再障的发病机理,有必要建立一种较理想的再障动物模型,为此我们通过免疫诱导的方法在小鼠身上较满意地诱导出再障,报告如下。 用H-2相同,Mls不同的BALB/c和DBA/2两种小鼠,分别作为受体和供体,先将BALB/c小鼠600rad的γ-射线全身照射后,于当天由尾静脉输入取自DBA小鼠全身淋巴结的淋巴结细胞,输入细胞量为1×10~8/只,对照组仅照射或输淋巴结细胞。观察指标有体重、红、白细胞、血小板、骨髓有核细胞计数、脾指数、股
In order to further explore the pathogenesis of aplastic anemia, it is necessary to establish a more ideal animal model of cataplasia, for which we induced more satisfactory in mice by immune-induced aplasia, reported as follows. BALB / c and DBA / 2 mice with the same H-2 and different BALB / c and DBA / 2 mice were used as recipients and donors respectively. Whole body irradiation of γ-rays of 600 rad in BALB / c mice was performed on the same day by tail vein The lymph node cells were collected from whole body lymph nodes of DBA mice. The amount of inputting cells was 1 × 10 ~ 8 per mouse, while the control group only irradiated or lost lymph node cells. Observe the indicators of weight, red, white blood cells, platelets, bone marrow nucleated cell count, spleen index, shares