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目的:探讨阿卡波糖对糖耐量异常(IGT)患者干预的临床疗效。方法:将我院门诊糖耐量异常患者106例随机分为两组,治疗组56例,在生活方式干预基础上给予阿卡波糖片50 mg,po,tid;对照组50例,仅给予生活方式干预。观察期间均进行糖尿病防治知识宣教,根据个体情况制定饮食及运动方案,观察12个月。结果:两组体重指数、血压、空腹血糖、葡萄糖负荷后2 h血糖、糖化血红蛋白、血脂等指标明显变化,治疗前、后差异均有统计性意义(P<0.01或<0.05)。治疗组糖尿病发生率为9.1%,明显低于对照组糖尿病发生率28%(P<0.05)。结论:阿卡波糖治疗IGT可明显降低糖尿病发生。
Objective: To investigate the clinical effect of acarbose on patients with impaired glucose tolerance (IGT). Methods: 106 cases of abnormal glucose tolerance in our hospital were randomly divided into two groups, 56 cases in the treatment group were given acarbose 50 mg, po, tid on the basis of lifestyle intervention; 50 cases in the control group were given only life Ways to intervene. During the observation period were all knowledge and education of diabetes prevention and control, according to individual circumstances to develop diet and exercise programs, observed for 12 months. Results: Body mass index, blood pressure, fasting blood glucose, blood glucose, glycated hemoglobin, blood lipid and other indexes were significantly changed after 2h of glucose load. The difference was statistically significant before and after treatment (P <0.01 or <0.05). The incidence of diabetes in the treatment group was 9.1%, which was significantly lower than that in the control group (28%, P <0.05). Conclusion: Acarbose treatment of IGT can significantly reduce the incidence of diabetes.