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脑脉宁属β-氨基酮衍生物,系中枢性肌松弛和血管扩张剂,作用于中枢神经系统和网状结构,特别是在肌张力调节中起决定性作用的网状结构尾部。选择性抑制多突触联系,改善大脑血液动力。此外,脑脉宁还具有直接血管扩张作用,可改善末梢血流。但对耳聋的治疗作用尚乏研究。作者对脑脉宁作用下的听感受器进行了直接观察,以了解该药对听器的作用情况,提出对耳毒性感音神经性聋预防和治疗的根据。实验以6只豚鼠为一组,共6组。以腹腔注射卡那霉素做成听器损害模式。剂量:卡那霉素50mg/kg/日,脑脉宁12mg/kg/日,均连续14天(与临床疗程相同)。第1、2组注射卡那霉素,第1组最后一次注射后处死;第2组注射两周后处死,第3组仅注射脑脉
Naomaining is a β-aminoketone derivative, a central muscle relaxation and vasodilator, acting on the central nervous system and reticular structures, especially in the tail of reticular structures that play a decisive role in muscle tone regulation. Selectively inhibit synaptic connections and improve cerebral hemodynamics. In addition, Naomaining also has a direct vasodilator effect, can improve peripheral blood flow. However, the treatment of deafness is still lacking in research. The author directly observes the hearing receptor under the action of Naomaining to understand the effect of the drug on the hearing aid and puts forward the basis for the prevention and treatment of ototoxicity. Experimental group of 6 guinea pigs, a total of 6 groups. To intraperitoneal injection of kanamycin into the hearing loss model. Dose: kanamycin 50mg / kg / day, brain vein rather 12mg / kg / day, were continuous for 14 days (with the same course of clinical treatment). Groups 1 and 2 were injected with kanamycin, and the first group was sacrificed after the last injection. The second group was sacrificed two weeks after the injection and the third group was injected with only the brain tumor