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目的:观察针刺加整脊手法对强直性脊柱炎(AS)患者躯体功能、血清碱性磷酸酶(ALP)、血沉(ESR)、C反应蛋白(CRP)及骨保护素(OPG)的影响.方法:将128例AS患者按随机数字表法分为对照组和观察组,每组64例.两组均接受口服柳氮磺胺吡啶及美洛昔康治疗,观察组在此基础上加用针刺和整脊手法.治疗8周后比较两组疗效、Bath AS功能指数评分(BASFI)以及Bath AS疾病活动指数(BASDAI)评分,以及ALP、ESR、CRP和OPG水平.结果:治疗后,两组各项中医症状评分均较治疗前下降(均P<0.05),且观察组各项评分均低于对照组(均P<0.05);两组VAS、BASFI及BASDAI评分均较治疗前下降(均P<0.05),且观察组三项评分均低于对照组(均P<0.05);两组ALP、ESR、CRP及OPG水平均较治疗前下降(均P<0.05),且观察组各项水平均低于对照组(均P<0.05).观察组总有效率92.2％,对照组为78.1％,两组差异有统计学意义(P<0.05).结论:药物治疗基础上加用针刺和整脊手法治疗AS可有效改善临床症状,促进患者躯体功能恢复,降低ALP、ESR、CRP和OPG水平.“,”Objective: To observe the effects of acupuncture plus spinal manipulations on the physical functioning and levels of alkaline phosphatase (ALP), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and osteoprotegerin (OPG) in patients with ankylosing spondylitis (AS). Methods: A total of 128 AS cases were allocated into a control group and an observation group using random number table method, with 64 cases in each group. Patients in both groups took sulfasalazine and meloxicam. Patients in the observation group received additional acupuncture plus spinal manipulations. The efficacy, Bath AS functional index (BASFI), Bath AS disease activity index (BASDAI), and the levels of ALP, ESR, CRP and OPG were compared between the two groups after eight weeks of treatment. Results: After treatment, the symptom scores of traditional Chinese medicine in both groups were decreased (all P<0.05), and these scores in the observation group were significantly lower than in the control group (all P<0.05); the VAS, BASFI and BASDAI scores in both groups were decreased (all P<0.05), and these scores in the observation group were significantly lower than in the control group (all P<0.05); and the ALP, ESR, CRP and OPG levels in both groups were decreased (all P<0.05), and these levels in the observation group were significantly lower than in the control group (all P<0.05). The total efficacy rate was 92.2％ in the observation group, versus 78.1％ in the control group, presenting a statistical significance (P<0.05). Conclusion: Conventional medication combined with acupuncture and spinal manipulations can improve clinical symptoms, accelerate the recovery of physical functioning, and reduce the ALP, ESR, CRP and OPG levels.