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目的探讨肾病结实合征(PNS)患者医院感染的原因和预防对策。方法对我院住院治疗的患者109例,进行医院感染分析。结果109例PNS患者医院感染率为66.6%,医院感染部位构成比依次为呼吸道、泌尿道、消化道;分离菌株以革兰阴性杆菌和真菌为主;血清IgG含量、住院时间、激素及免疫抑制剂与医院感染显著相关(P<0.01)。结论及早纠正患者蛋白营养不良,增强机体免疫力,防止肾功能损害或恶化将会对降低肾病综合征患者并发医院感染的发生起重要作用。加强医院感染管理,积极治疗原发病,做好病症本身护理,合理用药,提高患者自身免疫功能是预防医院感染的对策。
Objective To investigate the causes and prevention strategies of nosocomial infection in patients with nephrotic syndrome (PNS). Methods 109 hospitalized patients in our hospital were analyzed for nosocomial infection. Results The prevalence rate of nosocomial infection in 109 patients with PNS was 66.6%. The proportions of nosocomial infections were respiratory tract, urinary tract and gastrointestinal tract. Gram-negative bacilli and fungi were the main isolates. Serum IgG, length of hospital stay, hormones and immunosuppression Agents were significantly associated with nosocomial infections (P <0.01). Conclusion Early correction of patients with protein malnutrition, enhance immunity and prevent renal impairment or deterioration will reduce the incidence of nosocomial syndrome in patients with nosocomial infections play an important role. To strengthen the management of nosocomial infections, active treatment of the primary disease, good care of the disease itself, the rational use of drugs, improve patient’s own immune function is to prevent hospital infection.