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目的 评价肾移植术后供者特异性抗体 (Ds Ab)对移植肾近期效果的影响。方法 对2 0 0 1年 1月至 2 0 0 2年 7月间进行尸肾移植的 92例受者 ,使用酶联免疫吸附 (ELISA)法 ,检测受者血清中HLA抗体水平 ,随访 1年。结果 16例 (17.4 % )受者术后出现供者特异性抗体。抗体阳性组急性排斥发生率 (5 6 .3% )高于抗体阴性组 (11.9% ) ,P =0 .0 0 0 ;移植肾功能延迟恢复的发生率(12 .5 % )与抗体阴性组 (9.2 % )比较 ,差异无显著性 ,P =0 .10 2 ;供者特异性抗体阳性组受者发生急性排斥后 ,移植肾肌酐水平高于抗体阴性组或无急性排斥组。结论 供者特异性抗体与肾移植术后急性排斥有关 ,可能影响近期移植肾功能。
Objective To evaluate the effect of donor-specific antibody (Ds Ab) on the immediate effect of renal allograft after renal transplantation. Methods Ninety-two recipients of cadaveric kidney transplantation between January 2001 and July 2002 were enrolled in this study. Serum HLA antibodies were detected by enzyme-linked immunosorbent assay (ELISA) . Results 16 patients (17.4%) received donor-specific antibodies after operation. The incidence of acute rejection in antibody positive group (56.3%) was higher than that in antibody negative group (11.9%), P = 0.0000. The incidence of delayed graft recovery (12.5%) was negatively correlated with antibody negative group (9.2%), the difference was not significant (P = 0.10 2). After acute rejection in donor-specific antibody-positive group, the renal transplant creatinine level was higher than that in antibody negative group or without acute rejection group. Conclusion Donor-specific antibodies are associated with acute rejection after renal transplantation, which may affect recent renal graft function.