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目的了解乙肝病毒表面抗原(HBsAg)阳性孕妇中乙肝病毒(HBV)感染相关指标分布特征,以评价HBV母婴阻断失败高危因素的分布强度及影响因素。方法采用现况调查方法,对2009年8月-2010年12月期间入选的895名HBsAg阳性孕妇进行人口学信息、与HBV感染相关的信息调查,采集血液样品检测HBsAg、HBeAg、抗-HBe及HBV DNA滴度等指标,并对结果进行统计分析。结果 HBsAg阳性孕妇产前HBeAg阳性率为33.4%,HBV DNA载量>107IU/ml者占25.2%,HBsAg滴度≥10 000IU/mL者占29.61%;HBeAg阳性者中,HBsAg滴度与HBV DNA载量间存在密切正相关关系(r=0.53,P<0.01);随孕妇年龄的增加,孕妇产前HBeAg阳性率和HBV DNA载量均有明显降低趋势。结论 HB-sAg阳性孕妇中存在母婴阻断失败高危险因素的比例较高。适当推迟怀孕年龄,可降低HBsAg阳性人群HBV母婴阻断失败的风险。
Objective To investigate the distribution characteristics of hepatitis B virus (HBV) -related indicators in hepatitis B virus surface antigen (HBsAg) -positive pregnant women and to evaluate the distribution strength and influencing factors of high risk factors for failure of HBV maternal and neonatal blockade. Methods 895 HBsAg positive pregnant women selected from August 2009 to December 2010 were investigated by demographic information and information related to HBV infection. Blood samples were collected for the detection of HBsAg, HBeAg, anti-HBe and HBV DNA titer and other indicators, and the results of statistical analysis. Results HBeAg positive pregnant women prenatal HBeAg positive rate was 33.4%, HBV DNA load> 107IU / ml were 25.2%, HBsAg titer ≥ 10 000IU / mL accounted for 29.61%; HBeAg positive, HBsAg titer and HBV DNA (R = 0.53, P <0.01). With the increase of pregnant women’s age, the prenatal HBeAg positive rate and HBV DNA load of pregnant women were significantly decreased. Conclusion There is a high proportion of high risk factor for failure of maternal and child block in HB-sAg positive pregnant women. Proper postponement of pregnancy can reduce the risk of failure of HBV maternal and neonatal blockade in HBsAg-positive subjects.