自六十年代以来,随着抗高血压有效药物逐渐增多,国外报道高血压并发症略有控制,高血压心脏病和脑卒中患病率有所降低,但离开治疗高血压尚有一段距离。临床发现使用单个抗高血压药往往有不足之处,疗效提高受到限制,而采用常规剂量又常常产生较多的副作用。无论从药理学观点或临床治疗经验都提示几个药物的配伍处方,不仅可显著降低各药的常规剂量,提高疗效,并显著减少和减轻药物的副作用。 Since the 1960s, with the gradual increase in effective antihypertensive drugs, foreign reports slightly controlled the complications of hypertension, hypertension and stroke prevalence decreased, but there is still some distance away from the treatment of hypertension. Clinically, the use of a single antihypertensive drug often has shortcomings, increased efficacy is limited, and the use of conventional doses often have more side effects. No matter from pharmacological point of view or clinical experience have prompted the prescription of several drugs, not only can significantly reduce the conventional dose of each drug to improve efficacy, and significantly reduce and reduce the side effects of drugs.