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目的通过在急性中毒血液灌流(HP)中应用低分子肝素钠抗凝,研究其作为血液灌流抗凝剂的疗效。方法 HP治疗中毒24例,采用低分子肝素钠抗凝,治疗前及结束后测定活化部分凝血活酶时间(APTT)、凝血酶时间(TT)和血小板计数(PLT),观察患者出血、灌流器、管路凝血情况。结果 24例均顺利完成HP,其中5例出现灌流器凝血倾向,无一例发生出血、凝血;治疗前后APTT、TT及PLT无明显差异。结论低分子肝素钠作为HP治疗急性中毒中的抗凝剂,具有抗凝效果好、出血并发症少、安全可靠的特点。
Objective To study the curative effect of hemoperfusion anticoagulants by applying low molecular weight heparin anticoagulation in acute poisoning hemoperfusion (HP). Methods Twenty-four cases of HP were treated with low-molecular-weight heparin sodium anticoagulation. The APTT, TT and PLT were measured before and after treatment. Hemorrhage, Coagulation of the pipeline. Results All of the 24 patients successfully completed HP. Among them, 5 patients showed tendency of coagulation, no bleeding and coagulation occurred. There was no significant difference in APTT, TT and PLT before and after treatment. Conclusion Low molecular weight heparin as an anticoagulant in the treatment of acute poisoning has good anticoagulant effect, less bleeding complications, safe and reliable.