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报告2例以不规则多发性皮肤瘀斑和坏死为首发表现的抗磷脂抗体综合征。例1女,42岁。臀部及下肢大片瘀斑、坏死,血小板减少,抗核抗体、抗心磷脂抗体异常升高,补体降低,皮损组织病理示真皮血管有血栓存在。给予抗凝、血管扩张剂、糖皮质激素、免疫抑制剂和静脉注射用人免疫球蛋白等控制病情的同时,外科手术修复大片坏死皮肤。例2女,47岁。腹部、四肢大片瘀斑、水疱,抗心磷脂抗体异常升高,皮损组织病理示真皮浅层小血管血栓形成。给予糖皮质激素治疗及红光照射,皮损恢复较好。
Report of 2 cases with irregular multiple ecchymosis and necrosis as the first manifestation of antiphospholipid antibody syndrome. Example 1 Female, 42 years old. Buttocks and lower limb large ecchymosis, necrosis, thrombocytopenia, antinuclear antibodies, anti-cardiolipin antibodies abnormal increase, complement reduction, skin lesions showed dermal vascular thrombosis exist. Given anticoagulants, vasodilators, glucocorticoids, immunosuppressive agents and intravenous immunoglobulin control the disease at the same time, the surgical repair of large necrotic skin. Example 2 Female, 47 years old. Abdomen, large tracts of ecchymosis, blisters, anti-cardiolipin antibodies abnormalities, histological lesions of the dermis showed small blood vessel thrombosis. Give glucocorticoid treatment and red light irradiation, skin lesions better recovery.