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目的探讨血清肌红蛋白在阻塞性睡眠呼吸暂停综合征患者心肌损害早期诊断中的临床意义。方法选择经多导睡眠图监测仪监测确诊的28例阻塞性呼吸暂停综合征患者为患者组,根据呼吸暂停低通气指数(AHI)、血氧饱和度(SaO2)分为轻、中度组和重度组;另选择年龄、性别、体重指数(BMI)均相匹配的健康体检者28例为对照组。用免疫化学发光法检测各组Mb水平,比较各患者组与对照组、重度患者组治疗前后的各项指标的差异。结果重度阻塞性呼吸暂停综合征患者血清Mb水平显著高于健康查体人群(P<0.001);重度阻塞性呼吸暂停综合征患者nCPAP治疗后Mb水平显著下降(P<0.001)。结论血清肌红蛋白可作为阻塞性睡眠呼吸暂停患者心肌损害的早期预测指标。
Objective To investigate the clinical significance of serum myoglobin in the early diagnosis of myocardial damage in patients with obstructive sleep apnea syndrome. Methods Twenty-eight patients with obstructive apnea syndrome diagnosed by polysomnography were selected as patients and divided into mild and moderate groups according to apnea-hypopnea index (AHI) and oxygen saturation (SaO2) Severe group. Another 28 healthy subjects with matched age, gender and body mass index (BMI) were selected as the control group. The level of Mb in each group was detected by immunochemiluminescence method, and the differences of each index before and after treatment were compared between each group and the control group. Results Serum Mb levels in patients with severe obstructive apnea syndrome were significantly higher than those in healthy volunteers (P <0.001). Mb levels in patients with severe obstructive apnea syndrome were significantly decreased after nCPAP treatment (P <0.001). Conclusion Serum myoglobin may be an early predictor of myocardial damage in patients with obstructive sleep apnea.