【摘 要】
：
The mechanism and interaction among Rb/p16,Rb/E2F1 and HDAC1 proteins in gallbladder carcinoma were investigated. By using the immunoprecipitation method,the in
【机 构】
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Department of General Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science
【出 处】
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华中科技大学学报（医学）（英德文版）
论文部分内容阅读
The mechanism and interaction among Rb/p16,Rb/E2F1 and HDAC1 proteins in gallbladder carcinoma were investigated. By using the immunoprecipitation method,the interactions among Rb,pl6,E2F1,HDAC1 proteins in gallbladder carcinoma cell line (Mz-ChA-1) were studied.It was found that there were Rb and E2F1 proteins in the precipitates with anti-HDAC1,and there were HDAC1 and E2F1 proteins in the precipitate with anti-Rb. It was concluded that there are specific interactions among Rb,HDAC1 and E2F1 proteins in gallbladder carcinoma,indicating the existence of the direct Rb/E2F1/HDAC1 signal transduction pathway. There is no direct relationship between p16 proteins with Rb,HDAC1,and E2F1 proteins.
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