论文部分内容阅读
目的了解2010~2016年福建省腹泻患者沙门菌血清型分布和耐药情况。方法依据我省制定的伤寒、副伤寒及其他感染性腹泻监测方案,在我省3个地市设立沙门菌监测点开展工作。结果 2010~2016年福建省3个监测点共分离出174株沙门菌,均为肠道沙门菌内的亚种Ⅰ,分属于7个群(8个亚群),24个血清型,其中以B群血清型检出最多(29.20%)。血清型以鼠伤寒和肠炎沙门菌检出率最高(分别为50.60%和22.40%)。沙门菌总体耐药率为78.74%,其中氨苄西林、四环素和萘啶酸耐药率较高(分别为60.34%、57.47%、34.48%),环丙沙星和诺氟沙星耐药率最低。鼠伤寒和肠炎的耐药率分别为93.18%和92.31%,鼠伤寒以四环素和氨苄西林耐药为主,而肠炎以萘啶酸和氨苄西林为主。结论鼠伤寒仍是福建省重要的腹泻致病菌且耐药比较严重。
Objective To understand the distribution and drug resistance of Salmonella in Fujian diarrhea patients from 2010 to 2016. Methods According to the scheme of typhoid fever, paratyphoid fever and other infectious diarrhea developed in our province, Salmonella surveillance sites were established in 3 cities of our province. Results A total of 174 Salmonella isolates were isolated from 3 monitoring sites in Fujian Province from 2010 to 2016, all of which were subspecies Ⅰ in Salmonella enteritidis, belonging to 7 groups (8 subgroups) and 24 serotypes B group serotype detected the most (29.20%). The serotypes were the highest in S. typhimurium and S. Enteritidis (50.60% and 22.40%, respectively). The overall drug resistance rate of Salmonella was 78.74%, among which ampicillin, tetracycline and nalidixic acid were higher (60.34%, 57.47% and 34.48% respectively), and the lowest rates of resistance to ciprofloxacin and norfloxacin . The rates of resistance to typhoid and enteritis were 93.18% and 92.31%, respectively. Tetracycline and ampicillin resistance were the main pathogens in typhimurium, whereas nalidixic acid and ampicillin were the main enteritis in typhus. Conclusion Typhoid fever is still an important pathogen of diarrhea in Fujian Province and the drug resistance is more serious.