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目的以肾茶胶囊最大给药量给小鼠灌胃后,观察急性毒性反应及死亡情况,确定毒性靶器官。方法给小鼠灌服24h,每8h以最大体积(0.4mL/10g)、最大浓度肾茶胶囊(1.1508g/mL,相当于生药量11.5080g/kg)灌胃给药。结果给药14d内,小鼠的摄食、饮水、外观体征及活动情况无异常改变,体重增长正常,未见小鼠死亡;实验结束后处死动物并大体尸解,未见脏器有病理改变。结论肾茶胶囊毒性较低,可安全应用于临床。
OBJECTIVE To observe the acute toxicity and death of mice by intragastric administration of the maximum dose of Shen Cha capsule, and to determine the toxic target organ. Methods Mice were drenched with gavage for 24 hours every 8 hours. The maximum volume (0.4mL / 10g) and the maximum concentration of Shencha Capsule (1.1508g / mL, equivalent to 11.5080g / kg of crude drug) were intragastrically administered to mice. Results Within 14 days after administration, there was no abnormal changes in food intake, drinking water, appearance signs and activities of mice, normal weight gain and no death of mice. After the experiment, the animals were sacrificed and the autopsy was performed. No pathological changes were found in the organs. Conclusion Shen Cha capsule is less toxic and can be safely used in clinical practice.