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目的:探究炎性因子热休克蛋白27(HSP27)及C反应蛋白(CRP)在不同年龄组心房颤动(房颤)患者应激反应中血清的表达及其临床意义。方法:收集符合西医诊断标准的房颤患者60例,按不同年龄段分为A组(60~69岁)20例,B组(70~79岁)18例,C组(80~89岁)22例,正常对照组21例。取房颤患者发作当天静脉血4 m L,采用酶联免疫法(ELISA法)分别测定CRP及HSP27浓度,比较各组间血清CRP、HSP27水平差异。结果:A、B、C三组HSP27水平较对照组均显著升高(P<0.01),B组与C、A两组HSP27水平比较差异不明显(P>0.05),而C组HSP27浓度高于A组(P<0.01)。A组及C组CRP水平较对照组显著升高(P<0.01),而B组CRP浓度较对照组有升高趋势,但无统计学意义(P=0.078),C组较A、B两组CRP水平升高明显(P<0.01),A、B两组比较无明显差异(P=0.261)。结论:房颤的发生可能与炎症有关,炎性因子水平越高,房颤风险越高。HSP27及CRP水平对房颤的发生和维持起着重要的作用,其中HSP27的表达意义尤其突出,可以作为预测房颤发生的指标。
Objective: To investigate the expression of HSP27 and C-reactive protein (CRP) in the stress response of patients with atrial fibrillation (AF) in different age groups and its clinical significance. Methods: A total of 60 patients with atrial fibrillation meeting the diagnostic criteria of Western medicine were collected and divided into groups A (60-69 years) 22 cases, 21 cases of normal control group. Atrial fibrillation patients taking venous blood 4 m L, the use of enzyme-linked immunosorbent assay (ELISA) were measured CRP and HSP27 concentrations were compared between the serum CRP, HSP27 levels were compared. Results: The levels of HSP27 in group A, B and C were significantly higher than those in control group (P <0.01), while there was no significant difference in HSP27 between groups B and C (P> 0.05) In group A (P <0.01). CRP levels in group A and group C were significantly higher than those in control group (P <0.01), but CRP in group B was higher than that of control group (P = 0.078) The levels of CRP were significantly increased (P <0.01). There was no significant difference between groups A and B (P = 0.261). Conclusion: The occurrence of atrial fibrillation may be related to inflammation. The higher the level of inflammatory cytokines, the higher the risk of atrial fibrillation. The levels of HSP27 and CRP play an important role in the occurrence and maintenance of atrial fibrillation. The expression of HSP27 is of particular significance and can be used as an index to predict the occurrence of atrial fibrillation.