AIM:To investigate the efficacy of huperzine Ain treating child language delay and its side effects.METHODS:37children with language delay and o ther developmental diseases from pediatric neurology out-patient departme nt,who did not undergo any language rehabilitation,were treated with huperzin e A50μg bi-daily for more 3months and then th e efficacy and side effects observed.The follow-up was arranged to record the efficacy monthly.RESULTS:37cases of 40had undergone the whole course and the total efficiency was 68%(25/37).Language developments of other 12cases were not improved significantly.Other3children were not included in becau se epilepsy were observed among them.CONCLUSION:This pilot trial result suggests th at huperzine A has ef-ficacy on child language delay but sh ould be investigated further.Huperzine A may trigger seizure of language dela y patients with epilepsy. AIM: To investigate the efficacy of huperzine Aintering child language delay and its side effects. METHODS: 37children with language delay and o ther developmental diseases from pediatric neurology out-patient departme nt, who did not undergo any language rehabilitation, were treated with huperzin e A 50 μg bi-daily for more 3 months and then th e efficacy and side effects observed. The follow-up was arranged to record the efficacy monthly .RESULTS: 37 cases of 40 had undergone the whole course and the total efficiency was 68% (25/37 ). Language developments of other 12cases were not improved significantly. Yet 3children were not included in becau se epilepsy were observed among them. CONCLUSION: This pilot trial result suggests th at huperzine A has ef-ficacy on child language delay but should be further .Huperzine A may trigger seizure of language dela y patients with epilepsy.