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目的:探讨非小细胞肺癌同步放化疗引起放射性肺炎的相关影响因素。方法:回顾性分析我中心75例非小细胞肺癌进行三维适形放疗同步化疗后出现放射性肺炎的患者的一般情况,基础肺功能及其放疗靶体积和放疗剂量的关系。结果:75例患者中肿瘤完全缓解(CR)6例,占8%;部分缓解(PR)41例,占54.67%;稳定(NC)17例,占22.67%;进展(PD)11例,占14.67%。肿瘤临床获益率为85.33%。75例肺癌患者治疗后19例出现放射性肺炎,发生率为25.3%。其中患者的一般情况包括年龄及其放疗靶体积、放疗剂量和肺V20与放射性肺炎发生相关,是本组肺癌患者放化同步治疗后放射性肺炎发生的危险因素。结论:肺部基础情况差、放疗靶体积和靶区高剂量的非小细胞肺癌患者接受同步放化疗后易发生放射性肺炎。
Objective: To investigate the related factors of radiation pneumonitis caused by concurrent chemoradiotherapy in non-small cell lung cancer. Methods: A retrospective analysis of 75 patients with non-small cell lung cancer in our center for three-dimensional conformal radiation therapy after radiation pneumonitis in patients with general, basic lung function and radiotherapy target volume and radiotherapy dose. Results: The complete remission (CR) was found in 6 of 75 patients (8%), 41 (54.67%) were partially relieved (PR), 22.67% were stable (NC), and 11 were PD 14.67%. The clinical benefit rate of tumor was 85.33%. Radiation pneumonitis occurred in 19 of 75 lung cancer patients after treatment, with a rate of 25.3%. Among them, the general situation of patients, including age and radiotherapy target volume, radiotherapy dose and lung V20 associated with the occurrence of radiation pneumonitis, is the group of patients with lung cancer radiotherapy and chemotherapy after radiation pneumonitis risk factors. Conclusions: Radiographic pneumonia is likely to occur after concurrent chemoradiation in patients with non-small cell lung cancer who have poor lung conditions, high target radiation dose and high dose target.