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[目的]观察消渴汤联合西药治疗糖尿病肾病疗效。[方法]使用随机平行对照方法,将50例住院及门诊患者按掷骰子法简单随机分为两组。对照组25例二甲双胍,0.5g/次,3次/d,慢性肾病3a期减量,内生肌酐清除率<50m L/min停二甲双胍;慢性肾病3~4期用格列美脲,1~2mg/次,1次/d,起始剂量1mg/d;羟苯磺酸,1g/片,3次/d。治疗组25例消渴汤(党参10g,生黄芪20g,白术~炒10g,金樱子20g,芡实、白术、茯苓、山药各10g,黄精、菟丝子各20g,百合、枇杷叶各10g),1剂/d,水煎400m L,早晚口服;西药治疗同对照组。连续治疗70d为1疗程。观测临床症状、FPG、2h PG、HbAlC、Scr、UAE、BUN、不良反应。治疗1疗程,判定疗效。[结果]治疗组显效16例,有效8例,无效1例,总有效率96.00%。对照组显效7例,有效12例,无效6例,总有效率76.00%。治疗组疗效优于对照组(P<0.05)。治疗组生化指标均有改善(P<0.01),对照组FPG无改善(P>0.05),其余均有改善(P<0.01),治疗组改善优于对照组(P<0.05)。[结论]消渴汤联合西药治疗糖尿病肾病疗效满意,无严重不良反应,值得推广。
[Objective] To observe the curative effect of Diabetes Decoction combined with western medicine on diabetic nephropathy. [Methods] Using randomized parallel control method, 50 inpatients and outpatients were randomly divided into two groups according to the dice method. Control group 25 metformin, 0.5g / time, 3 times / d, reduction of chronic kidney disease 3a, creatinine clearance rate <50m L / min metformin; chronic nephritis 3 to 4 with glimepiride, 2mg / time, 1 time / d, the initial dose of 1mg / d; hydroxybenzene sulfonic acid, 1g / tablet, 3 times / d. Treatment group, 25 cases of Diabetes Decoction (Codonopsis 10g, raw Astragalus 20g, Atractylodes ~ fried 10g, Rosa laevigata 20g, Gorgon, Atractylodes, Poria, yam 10g, Polygonatum, Dodder 20g, lily, loquat leaves each 10g), 1 Agent / d, decoction 400m L, morning and evening oral; Western medicine treatment with the control group. Continuous treatment of 70d for a course of treatment. Clinical symptoms, FPG, 2h PG, HbAlC, Scr, UAE, BUN were observed. Adverse reactions were observed. Treatment of a course of treatment to determine the efficacy. [Result] The treatment group was markedly effective in 16 cases, effective in 8 cases, ineffective in 1 case, the total effective rate was 96.00%. The control group markedly effective in 7 cases, effective in 12 cases, 6 cases, the total effective rate 76.00%. The treatment group was better than the control group (P <0.05). The biochemical indexes in the treatment group were improved (P <0.01), the FPG in the control group was not improved (P> 0.05), the rest were improved (P <0.01), and the treatment group improved better than the control group (P <0.05). [Conclusion] Xiaoxie decoction combined with western medicine has satisfactory curative effect on diabetic nephropathy without serious adverse reactions and is worth promoting.