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介绍了毛发中甲基苯丙胺（ MAMP）及代谢产物苯丙胺（ AMP）的 GC/NPD、 GC/MS的定性定量分析方法。毛发用 0.1 mol/L HCl水解， 4－苯基丁胺（ 4－ PBA）为内标，液－液提取，三氟乙酸酐（ TFA）衍生化。毛发用量为 10mg，检出限为 GC/NPD 0.5ng/mg， GC/MS 0.1ng/mg，回收率大于 78％。该方法成功应用于染毒豚鼠毛发中 MAMP及其代谢产物 AMP浓度变化过程的测定。
The qualitative and quantitative methods for the determination of methamphetamine (MAMP) and amphetamine (AMP) in hair by GC / NPD and GC / MS were introduced. Hair was hydrolyzed with 0.1 mol / L HCl, 4-phenylbutylamine (4-PBA) was used as internal standard, liquid-liquid extraction and trifluoroacetic anhydride (TFA) derivatization. The amount of hair was 10mg, the detection limit was GC / NPD 0.5ng / mg, GC / MS 0.1ng / mg, the recovery was more than 78%. The method was successfully applied to the determination of the change of AMP concentration in MAMP and its metabolite in guinea pig hair.