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目的 采用声学密度法,观察实验动物犬心腔内不同类型造影剂后散射强度的变化,分析微气泡成分的不同对收缩期压力的敏感性。方法 经多巴酚丁胺逐步升压后,周围静脉分别注射声振白蛋白造影剂、Levovist和含氟碳造影剂,记录改变收缩期压力时不同类型造影剂的后散射二维图像,并与右室压力曲线同步。结果 收缩期压力对声振白蛋白造影剂和Levovist后散射强度之差(ED ES)的影响差异具有显著性意义(P<0.0001, P<0.02),对含氟碳造影剂后散射强度之差的影响差异无显著性意义(P=0.10)。收缩期压力与声振白蛋白造影剂后散射强度之差的相关性较好(r=0.64, P<0.0001),与Levovist的相关性次之(r=0.57,P=0.001),与含氟碳造影剂相关性差(r=0.41, P=0.07)。结论 造影剂微气泡外壳成分和内部气体的性质影响其对外周压力变化的敏感性。声振白蛋白微气泡外壳弹性较好,内含可压缩的空气,对收缩期压力变化的敏感性较高,Levovist次之,含氟碳造影剂外壳较坚硬,对压力变化的敏感性低。
Objective To observe the changes of the scattering intensity of different types of contrast agents in the experimental animal canine heart by acoustic density method and analyze the sensitivity of different microbubble components to the systolic pressure. Methods After the dobutamine was gradually boosted, the contrast-enhanced ultrasound contrast agent, Levovist and fluorocarbon contrast medium were injected into the peripheral vein to record the two-dimensional images of different types of contrast agents after changing the systolic pressure. Right ventricular pressure curve synchronization. Results The effect of systolic pressure on the difference of ED ES between contrast agent and Levovist contrast agent was significant (P <0.0001, P <0.02) The difference was not statistically significant (P = 0.10). (R = 0.64, P <0.0001), and Levovist correlation (r = 0.57, P = 0.001), and the correlation between systolic pressure and sound contrast albumin contrast agent scattering intensity (r = Carbon contrast agents were poorly correlated (r = 0.41, P = 0.07). Conclusions The properties of contrast agent microbubble shell composition and internal gas affect its sensitivity to changes in peripheral pressure. Acoustic albumin microbubbles shell elasticity is good, containing compressible air, the sensitivity of systolic pressure changes, Levovist second, fluorocarbon contrast agent is more rigid shell, the sensitivity of the pressure change is low.