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目的:观察茜草与茜草炭对急性血瘀模型大鼠的影响,揭示两者在功效方面的异同。方法:皮下注射肾上腺素加冰水浸泡复制大鼠急性血瘀模型,以云南白药为阳性对照,连续给药7 d,利用此模型观察茜草与茜草炭高、中、低各3个剂量组对血液流变学、凝血酶活性及血小板系统的影响。结果:茜草能够显著改善不同切变率下血瘀模型大鼠的全血黏度及血浆黏度,在止血方面体现了一定的双向调节,对由ADP诱导的血小板聚集率表现出一定的影响,但弱于茜草炭。茜草炭主要通过影响内、外源性凝血酶以及纤维蛋白原来达到促凝效果,能明显提高血瘀模型大鼠血小板聚集率(P<0.01)。结论:茜草既能化瘀,又能止血,茜草炭主要发挥其止血作用,进一步论证了茜草、茜草炭“生行熟止”的传统炮制理论。
Objective: To observe the effects of madder and madder carbon on acute blood stasis model rats, and to reveal the similarities and differences between the two in efficacy. Methods: Subcutaneous injection of epinephrine and ice-water soaked in acute blood stasis model rats, Yunnanbaiyao positive control, continuous administration of 7 d, the use of this model of Rubia cordifolia and madder carbon high, medium and low of the three dose groups Hemorheology, thrombin activity, and the effects of platelet system. Results: Rubia Cordifolia can significantly improve the whole blood viscosity and plasma viscosity of blood stasis model rats at different shear rates, showing some bi-directional regulation in hemostasis, and have a certain influence on platelet aggregation rate induced by ADP, but weak Rubescens charcoal. Rubiaceae charcoal mainly achieved the procoagulant effect by affecting the exogenous thrombin and fibrinogen, and significantly increased the platelet aggregation rate in the blood stasis model rats (P <0.01). Conclusion: Rubia Cordyceps both stasis and hemostasis, Rubia cordifolia mainly play its role in hemostasis, and further demonstrated the Rubia cordifolia, Rubia cordifolia “Sachis ” traditional processing theory.