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近年的临床报道,胆囊摘除后大肠癌的发生率有所增高。胆囊摘除与大肠癌之间的因果关系因而引人注目。本文作者用致癌物质 N-methyl-N’-nitro-N-nitrosoguanidine(简称 MNNG)做诱发大肠癌实验,以探讨胆囊摘除所产生的影响.主要对胆囊摘除后胆管胆汁和粪便中胆酸的组成进行了探讨,并报道其结果。材料与方法实验动物为300g 左右的雌性豚鼠,分为两组,实验组做胆囊摘除,对照组单纯开腹。用 0.025%MNNG 液体2.0ml(0.5mg)每周两次经直肠注入,注射15周(共15mg)。在实验开始40周后实验动物全部处
In recent clinical reports, the incidence of colorectal cancer after gallbladder removal has increased. The causal relationship between gallbladder removal and colorectal cancer has drawn attention. The authors used the carcinogen N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) as the inducer of colorectal cancer to study the effect of gallbladder removal. The main components of bile acid in bile duct and feces after gallbladder removal We discussed and reported the results. Materials and Methods The experimental animals were female guinea pigs of about 300 g and were divided into two groups. The experimental group performed gallbladder removal, and the control group had simple laparotomy. 2.0 ml (0.5 mg) of 0.025% MNNG fluid was injected rectally twice a week for 15 weeks (total 15 mg). 40 weeks after the start of the experiment