论文部分内容阅读
目的以脱乙酰壳聚糖为药物载体,制备了葛根素壳聚糖微球,考察葛根素壳聚糖微球在体外药物释放特性。方法以液体石蜡为油相,采用乳化-交联法制备葛根素壳聚糖微球,高效液相色谱法测定葛根素的含量。结果制备的葛根素壳聚糖微球形态圆整,大小均匀,表面光滑,平均粒径为9.56μm,葛根素包封率为72.20%,平均载药量为17.82%。结论体外药物释放结果显示:以壳聚糖为载体,采用乳化-交联法制备的葛根素壳聚糖微球具有良好的缓释效果。
OBJECTIVE To prepare puerarin chitosan microspheres by chitosan as drug carrier and investigate the drug release characteristics of puerarin chitosan microspheres in vitro. Methods The liquid paraffin was used as the oil phase, and the puerarin-chitosan microspheres were prepared by emulsification-crosslinking method. The content of puerarin was determined by high performance liquid chromatography. Results The prepared puerarin chitosan microspheres were round in shape, uniform in size and smooth in surface. The average particle size was 9.56 μm. The encapsulation efficiency of puerarin was 72.20% and the average drug loading was 17.82%. Conclusion The results of in vitro drug release showed that puerarin chitosan microspheres prepared by emulsification-crosslinking method had good sustained-release effect with chitosan as carrier.