论文部分内容阅读
动脉粥样硬化、心房颤动等疾病危害着人类的健康,研究表明NF-κB信号通路及血管间粘附分子等在这些疾病中发挥着重要的作用,因此对NF-κB信号通路及血管间粘附分子等的研究可以为这些疾病的预防与治疗提供重要的理论依据。TNF-α等多种细胞因子可以激活NF-κB信号通路,进而显著增加血管间粘附因子等的表达,从而影响动脉粥样硬化、心房颤动等疾病的产生与发展。麝香乌龙丸、来氟米特、丹皮酚与利拉鲁肽等药物可通过抑制NF-κB信号通路来降低血管间粘附分子等的浓度,进而预防与治疗相关的疾病。该文综述了NF-κB信号通路与血管间粘附分子在疾病的产生、发展中的作用以及以它们为靶点治疗疾病的简要机制,旨在为相关疾病的预防、治疗提供有价值的参考。
Atherosclerosis, atrial fibrillation and other diseases endanger human health, studies have shown that NF-κB signaling and vascular intercellular adhesion molecules play an important role in these diseases, so the NF-κB signaling pathway and intervascular adhesion Additional studies such as molecules can provide an important theoretical basis for the prevention and treatment of these diseases. TNF-α and other cytokines can activate NF-κB signaling pathway, and then significantly increase the expression of inter-vascular adhesion factors, thereby affecting the atherosclerosis, atrial fibrillation and other diseases and development. Drugs such as muskmelon pill, leflunomide, paeonol and liraglutide can reduce the concentration of inter-vascular adhesion molecules by inhibiting the NF-κB signaling pathway, thereby preventing the treatment-related diseases. This review summarizes the roles of NF-κB signaling and intervascular adhesion molecules in the pathogenesis and progression of diseases, and provides a brief overview of the mechanisms by which they are targeted for the prevention and treatment of related diseases. .