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目的：比较目前常用的 Ｃ Ｅ、 Ｅ Ｐ 化疗方案治疗小细胞肺癌的疗效。方法：１９９６ 年１ 月～１９９８ 年１０ 月应用小细胞肺癌病人８９ 例，应用 Ｃ Ｅ、 Ｅ Ｐ、 Ｔ Ｐ 方案治疗观察疗效和不良反应。结果：局限期３７ 例（４１６ ％ ） ，广泛期５２ 例（５８４ ％ ） 。初治１９ 例（６６３ ％ ） ，复治３０ 例（３３７ ％ ） 。化疗２ 周以上者作疗效评价，８９ 例中有８４ 例可评价。全组总有效率（ Ｃ Ｒ ＋ Ｐ Ｒ） ７６２ ％ ， 其中局限期、广泛期病例分别为８９５ ％ 、６５２ ％ （ Ｐ＜ ００１） ，初、复治病例分别为８３１ ％ 、６００ ％ （ Ｐ＜ ００２５） 。 Ｃ Ｅ、 Ｅ Ｐ、 Ｔ Ｐ 各组疗效分别为７０７ ％ 、７９５ ％ 、７５ ％ （ Ｐ＞ ０１） 。结论：各组化疗方案对小细胞肺癌均有较高的缓解率，特别是局限期或初治病例，但前两组方案对广泛期或复治病例疗效较差。 Ｔａｘｏｌ 联合 Ｄ Ｄ Ｐ 治疗小细胞肺癌疗效较高。
OBJECTIVE: To compare the curative effects of currently used C E, E P chemotherapy regimens in the treatment of small cell lung cancer. Methods: From January 1996 to October 1998, 89 patients with small cell lung cancer were treated with C E, E P, and T P regimens to observe the efficacy and adverse reactions. Results: The limitation period was 37 cases (41.6%), and the extensive stage was 52 cases (58.4%). Nineteen cases (66. 3%) were initially treated and 30 cases (33.7%) were retreated. Efficacy evaluation was performed for patients who were more than 2 weeks of chemotherapy, and 84 of 89 patients were evaluated. The total effective rate (C R + P R) was 76. 2%, of which the patients with limited and extensive periods were 89.5% and 65. 2% respectively (P < 0. 01). The initial and retreatment cases were 831 %, 600 % ( P< 0025). The efficacy of C E, E P, T P in each group was 70.7%, 79.5%, 75% (P > 0. 1). Conclusion: The chemotherapy regimens of all groups have a high remission rate for small cell lung cancer, especially for patients with limited or untreated cases, but the first two groups have poor efficacy for extensive or retreatment cases. Taxol combined with D D P is highly effective in the treatment of small cell lung cancer.