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HIF-1是Semenza GL等[1]1992年发现的一种氧依赖转录激活因子,HIF-1的发现使人们对缺氧缺血状态下机体的各种应答反应机制的研究更加深入。HIF-1是细胞中调节血管生成主要缺氧反应信号蛋白,它能诱导多达70多种转录因子[2],包括促红细胞生成素(EPO)、糖酵解酶、诱导型一氧化氮合
HIF-1 is an oxygen-dependent transcriptional activator discovered by Semenza GL et al. [1] in 1992. The discovery of HIF-1 further explores various mechanisms of response to hypoxia-ischemia in the body. HIF-1 is a major hypoxia-responsive signaling protein that regulates angiogenesis in cells and can induce up to 70 transcription factors [2], including erythropoietin (EPO), glycolytic enzymes, inducible nitric oxide synthase