论文部分内容阅读
目的:探讨阿托伐他汀以及辛伐他汀应用于急性脑梗塞(ACI)患者的调脂效果。方法:选取ACI患者84例,将患者按照随机数字表分法分为辛伐他汀组和阿托伐他汀组,每组42例。辛伐他汀组给予辛伐他汀20mg/d口服;阿托伐他汀组给予阿托伐他汀20mg/d口服。比较两组患者治疗前后的血浆血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平。结果:两组患者治疗前后的TC、LDL-C、TG在血浆中的浓度均明显降低,但与辛伐他汀组相比,阿托伐他汀组患者血浆浓度下降的水平更加明显,组间比较差异有统计学意义(P<0.05)。结论:采用2种他汀类药物均可以改善ACI患者的血脂水平,但阿托伐他汀效果更优。
Objective: To investigate the lipid-lowering effect of atorvastatin and simvastatin in patients with acute cerebral infarction (ACI). Methods: Eighty-four patients with ACI were divided into simvastatin group and atorvastatin group according to random number table. Simvastatin 20mg / d was given to simvastatin group and 20mg / d of atorvastatin was given to atorvastatin group. The levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C) in two groups before and after treatment were compared. Results: The levels of TC, LDL-C and TG in plasma before and after treatment in both groups were significantly lower than those in simvastatin group, but plasma concentrations in atorvastatin group were more obvious than those in simvastatin group The difference was statistically significant (P <0.05). Conclusion: Both statins can improve blood lipids in patients with ACI, but atorvastatin is more effective.