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本文采用遗传流行病学病例对照研究方法 ,探讨遗传因素在胃癌病因中所起的作用 ,并研究胃癌的家族聚集性。结果病例组有胃癌家族史的比例 (22.53% )显著高于对照组 (10.79% ) ,病例组一级亲属患胃癌的比例 (3.21% )高于对照组(1.44% ,OR=2.27,95%CI1.38～3.73)。用(p+q)n 模型拟合结果家族中实际病例数的分布高于二项分布的概率范围 ,经频数分布拟合优度的检验 ,P<0.01,说明胃癌在家族中并非按机会均等的概率分布 ,而是呈现明显的家族聚集现象 ,胃癌家族史是胃癌发生的危险因素。
This article uses a genetic epidemiology case-control study method to explore the role of genetic factors in the etiology of gastric cancer, and to study the family clustering of gastric cancer. Results The proportion of patients with family history of gastric cancer (22.53%) was significantly higher than that of the control group (10.79%). The proportion of first-degree relatives with gastric cancer (3.21%) was higher in the case group than in the control group (1.44%, OR = 2.27, 95%). CI1.38 to 3.73). The distribution of actual cases in the family fitted with the (p+q)n model was higher than the probability range of the binomial distribution, and the test of frequency distribution goodness-of-fit, P<0.01, showed that gastric cancer was not equalized in the family. The probability distribution, but showed a clear phenomenon of family aggregation, family history of gastric cancer is a risk factor for gastric cancer.