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采用ELISA夹心法对食管癌患者手术前后血清可溶性白细胞介素2受体（sIL－2R）水平进行了动态观察，结果发现，有手术指征的食管瘤患者组血清sIL－2R水平（407±99u／ml）非常显著地高于正常对照组（265±88u／ml）（P＜0．001），其中Ⅰ、Ⅲ组食管癌患者手术前后血清sIL－2R水平明显下降（Ⅰ组：术前；375±52u／ml术后：259±39u／ml；Ⅲ组：术前：383±73u／ml术后：260±64u／ml），而Ⅲ组病人手术前后血清sIL－2R水平无明显差异；部分术后追踪观察发现，复发者血清sIL－2R水平（959±143u／ml）与未复发者（345±78u／ml）有显著性差异（P＜0．001）．该研究结果说明血清sIL－2R水平在指导外科医生明确手术指征，选择手术方式、估计预后上有较为重要的参考价值。
The level of serum soluble interleukin 2 receptor (sIL-2R) in patients with esophageal cancer before and after operation was measured by ELISA. The results showed that serum sIL-2R levels in patients with surgical indications of esophageal tumors (407±99u) (/ml) was significantly higher than the normal control group (265±88u/ml) (P<0.001), among which, serum sIL-2R levels in patients with esophageal cancer in group I and III were significantly decreased before and after surgery (group I: preoperative; 375±52u/ml postoperatively: 259±39u/ml; Group III: preoperatively: 383±73u/ml postoperatively: 260±64u/ml), and there was no significant difference in serum sIL-2R levels before and after operation in Group III patients. Some postoperative follow-up observations revealed that serum sIL-2R levels (959±143u/ml) were significantly different from those without relapse (345±78u/ml) (P<0.001). The results of this study show that serum sIL-2R levels are of relatively important reference value in guiding surgeons to identify surgical indications, selecting surgical methods, and estimating prognosis.