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目的探究连续性血液净化(CBP)在重症监护病房(ICU)多器官功能障碍综合征患者中的应用价值。方法选取2014年10月至2015年4月吉林医药学院附属医院收治的32例ICU多器官功能障碍综合征患者作为研究对象,所有患者均行常规治疗,在此基础上采用CBP治疗,观察患者的临床疗效并比较治疗前后尿素氮(BUN)、血肌酐(SCr)和超敏C反应蛋白(hs-CRP)水平以及急性生理学及慢性健康状况评分系统(APACHEⅡ)评分。结果经CBP治疗后,32例患者中,病死7例,病死率为21.9%(7/32);病死原因:重型感染4例,呼吸衰竭2例,心脏猝停1例;治疗后患者BUN、Scr、hs-CRP水平及APACHEⅡ评分均明显低于治疗前,差异均有统计学意义(均P<0.05)。结论采用CBP治疗ICU多器官功能障碍综合征,可明显改善患者临床症状,降低BUN、Scr和hs-CRP水平,提高健康指数和生命质量。
Objective To investigate the value of continuous blood purification (CBP) in patients with multiple organ dysfunction syndrome in intensive care unit (ICU). Methods From October 2014 to April 2015, 32 ICU patients with multiple organ dysfunction syndrome admitted to the Affiliated Hospital of Jilin Medical College were selected as the study subjects. All patients underwent routine treatment. CBP was used to treat the patients The clinical efficacy and the levels of BUN, SCr and hs-CRP before and after treatment were compared with those of acute physiology and chronic health assessment score (APACHEⅡ). Results After CBP treatment, 7 cases died and the case fatality rate was 21.9% (7/32). The cause of death was 4 cases of severe infection, 2 cases of respiratory failure and 1 case of sudden cardiac arrest. After treatment, BUN, Scr, hs-CRP levels and APACHE Ⅱ scores were significantly lower than before treatment, the difference was statistically significant (P <0.05). Conclusion CBP treatment of ICU multiple organ dysfunction syndrome can significantly improve the clinical symptoms, reduce the levels of BUN, Scr and hs-CRP, improve the health index and quality of life.