目的：观察红背丝绸２种提取物和单体（ＣＡ１２０１）对内皮素１（ｅｎｄｏｔｈｅｌｉｎ１，ＥＴ１）生物效应的拮抗作用。方法：用红背丝绸３种提取物对ＥＴ１致小鼠急性死亡、血管收缩和升压作用的拮抗，探索用中草药拮抗ＥＴ的生物效应。结果：３种提取物对ＥＴ１致小鼠急性死亡有明显的保护作用，使小鼠的死亡率下降；并可拮抗ＥＴ１致胸主动脉的缩血管效应，醇提物和乙酸乙酯提取物（１０－７母液）拮抗ＥＴ缩血管效应分别为５７．２７％和５８．６１％；ＣＡ１２０１１０－８ｍｏｌ·Ｌ－１和１０－９ｍｏｌ·Ｌ－１亦能拮抗ＥＴ１的缩血管效应；醇提物和乙酸乙酯提取物ｉｇ及ＣＡ１２０１ｉｖ后能拮抗ＥＴ１的升压作用，拮抗ＥＴ１作用均呈现明显的剂量依赖性。结论：红背丝绸２种提取物和ＣＡ１２０１可拮抗ＥＴ１的生物学效应 Objective: To observe the antagonistic effects of two kinds of extracts and monomers (CA1201) of red back silk on the biological effects of endothelin1 (ET1). METHODS: Three kinds of extracts from red-backed silk were used to antagonize acute death, vasoconstriction and pressure increase induced by ET1 in mice. The use of Chinese herbal medicines was explored to antagonize the biological effects of ET. RESULTS: The three extracts had obvious protective effects on acute death of mice induced by ET1, which reduced the mortality rate of mice, and could antagonize the vasoconstrictor effect of thoracic aorta induced by ET1. The antagonism of ET vasoactive effects by ester extracts (10-7 mother liquor) was 57.27% and 58.61%, respectively. CA120110-8mol·L-1 and 10-9mol·L-1 also antagonized ET1. The vasoconstrictive effect; ethanol extract and ethyl acetate extract ig and CA 1201iv can antagonize the vasopressor action of ET  1 and antagonize the effects of ET  1 in a dose-dependent manner. Conclusion: Two kinds of extracts of red back silk and CA1201 can antagonize the biological effects of ET1